Buffalo Bills Rams

The reigning Super Bowl Champions (the Rams) will aim to get off to a winning start against last year’s AFC Number 3 seed (the Bills).

The Rams overcame Joe Burrow and the AFC Divisional Round.

These two come into the season as two of the favorites to lift the Lombardi Trophy in Arizona in February. The Rams are stacked with big-name talent and contracts to match. Star Quarterback Matthew Stafford made good on the Rams’ investment last season and delivered a long-awaited ring for LA. Defensive phenom Aaron Donald was rewarded for the championship run with a record contract worth $30m a season.

The Buffalo Bills are also primed for a big season. With signal caller Josh Allen under center, they will be hoping to go one better than last year and reach the franchise’s first Super Bowl since the 1990s. Pro Bowl wide receiver Stefon Diggs and second-round rookie running back James Cook provide some of the firepower on offense.

This matchup of NFL betting odds spread only going 1 point either way. Look for a high-scoring affair to start the season in primetime. Both these teams have significant offensive weaponry to cover the “over” on the total points, and both teams finished last season in good scoring form.

If you’re someone who likes to bet on NFL games, the home team has won 7 of the last 9 NFL openers. The safe option might be to go with the Rams defending their house and securing an opening night W.